Handbook Of Photodynamic Therapy: Updates On Recent Applications Of Porphyrin-based Compounds

Handbook Of Photodynamic Therapy: Updates On Recent Applications Of Porphyrin-based Compounds

Updates on Recent Applications of Porphyrin-Based Compounds

Ravindra K Pandey, David Kessel;Thomas J Dougherty


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The main objective of this book is to present the recent applications of photodynamic therapy (PDT) in treating cancer and other diseases. The limitations associated with current PDT agents, and the synthetic designs that have been used in various laboratories are also discussed. The utility of certain tumor-avid agent for cancer imaging (fluorescence, PET, MRI) is also summarized. The book also includes the use of delivery vehicles, including nanoparticles in improving the tumor-specificity of the desired agents. The book is basically focused on the translational approach of drug development. By providing certain specific examples, a clear concept of moving a "product" from the bench to bed-side is also discussed. To have a clear concept of drug development the book is divided in three parts — Medicinal Chemistry, Mechanistic and Clinical studies. Each part includes the contributions from the leading scientists with extensive experience in the respective field. The handbook is assembled by renowned scientists Dr Dougherty, known as the father of PDT, Dr Kessel, well known for his contributions on mechanism of PDT and Dr Pandey for his inventions in developing improved agents for PDT and cancer-imaging.Contents: Part 1: Multifunctional Agents for Cancer-Imaging and Photodynamic Therapy: Impact of Polyacrylamide-Based Nanoplatforms (Aimee Marko, Nayan J Patel, Penny Joshi, Joseph R Missert and Ravindra K Pandey) Design and Synthesis of Photosensitizer-Peptide Conjugates for PDT (Tyrslai M Williams, Martha Sibrian-Vazquez and M Graça H Vicente) Current Developments in Using MESO-(TETRA) Substituted Porphyrins for PDT (Yasser M Shaker, Ayman M K Sweed, Claire Moylan, Luke Rogers, Aoife A Ryan, Rosine Petitdemange and Mathias O Senge) Core-Modified Porphyrins as Photosensitizers in Photodynamic Therapy (Michael R Detty) Phthalocyanines in Cancer-Imaging and Therapy (Hasrat Ali and Johan E van Lier) Molecular Phthalocyanine-Based Photosensitizers for Photodynamic Therapy (Pui-Chi Lo, Sun Y S Chow and Dennis K P Ng) Porphyrin Nanoparticles for Cancer Imaging and Phototherapy (Liyang Cui, Juan Chen and Gang Zhengg) Photodynamic Therapy Dosimetry: A TO Z (Michael S Patterson) Part 2: PDT: Death and Survival Pathways (David Kessel) Vascular Effects of Photodynamic Therapy for Tumors (Keith A Cengel, Charles B Simone and Theresa M Busch) EtNBS in Photodynamic Therapy (Nicholas H Nowell, Hsin-I Hung, Lauren A Austin and Conor L Evans) Negative Impact of Tumor-Generated Nitric Oxide on Photodynamic Therapy (Albert W Girotti) On the Use of Photodynamic Therapy, as Monotherapy or in Combination, in the Treatment of Polypoidal Choroidal Vasculopathy: An Update (Hubert van den Bergh and Patrycja Nowak-Sliwinska) Part 3: Photodynamic Therapy of Head and Neck Cancer — What's Old and What's New (Merrill A Biel) Endoscopic Photodynamic Therapy for Advanced Inoperable Esophageal Cancer (Joerg Lindenmann) PDT for Lung Cancer (Keishi Ohtani and Norihiko Ikeda) New Developments in Antimicrobial PDT (Wolfgang Bäumler) Antimicrobial Effects of Photosensitized Silicon Phthalocyanine (Pc) 4 (Minh Lam, Matthew L Dimaano, Pranab K Mukherjee, Mahmoud A Ghannoum, Nancy L Oleinick and Elma D Baron) Photofrin-PDT from Bench to Bedside: Some Lessons Learned (Julia Levy and Ed Levy)Readership: This book should be useful for oncologists, pharmacologists, chemists, biologists, physicists, and biochemists involved in cancer research, as well as graduate-level students in these disciplines.Photodynamic Therapy; Cancer Imaging; Multifunctional Agents; Nanoparticles Key Features: Rationale for drug design, especially for developing candidates for both cancer-imaging and therapy Importance of drug delivery vehicles for enhanced tumor-specificity How to move a product from bench to bed side? Obstacles and solutions