Cancer Cell Chemoresistance and Chemosensitization

Cancer Cell Chemoresistance and Chemosensitization

Ajaikumar B Kunnumakkara, Devivasha Bordoloi, Javadi Monisha

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Description

Despite the significant advances in cancer therapy made through constant evaluation and analysis of treatment aftereffects, the disease still remains one of the foremost causes of mortality worldwide killing more than 12 million people annually. The prime reason behind the failure of conventional chemotherapeutics which are used as the chief regimen in the comprehensive treatment of cancers is the development of chemoresistance. It can be either intrinsic or acquired and is primarily mediated via different key regulators like MDR, MAPK, NF-κB, PI3K/Akt, Wnt signaling pathways etc. Thus, agents which can target these regulatory elements or pathways and in turn sensitize cancer cells to chemotherapy holds immense prospect. However, there is barely such comprehensive work available in scientific literature that explains how chemosensitization of cancer cells functions using different drug combinations and exhibit synergism. This book provides a detailed description of chemoresistance and chemosensitization, targets for chemosensitization and various approaches adapted in the process of chemosensitization. Furthermore, the book explicates the role of various chemosensitizers, both natural and synthetic in sensitizing cancer cells and also details the current research findings on chemosensitization of different cancer types in both pre-clinical and clinical settings.

Contents:
  • Introduction and Basic Concepts of Cancer (Devivasha Bordoloi, Bethsebie Lalduhsaki Sailo, Nafiseh Manteghi, Ganesan Padmavathi and Ajaikumar B Kunnumakkara )
  • Cancer Cell Chemoresistance: A Prime Obstacle in Cancer Therapy (Javadi Monisha, Aviral Jaiswal, Kishore Banik, Harsha Choudhary, Anuj Kumar Singh, Devivasha Bordoloi and Ajaikumar B Kunnumakkara)
  • Bladder Cancer: Chemoresistance and Chemosensitization (Nand Kishor Roy, Anand Sharma, Anuj Kumar Singh, Devivasha Bordoloi, Bethsebie Lalduhsaki Sailo, Javadi Monisha and Ajaikumar B Kunnumakkara)
  • Mechanism of Chemoresistance in Bone Cancer and Different Chemosensitization Approaches (Ganesan Padmavathi, Devivasha Bordoloi, Kishore Banik, Javadi Monisha, Anuj Kumar Singh and Ajaikumar B Kunnumakkara)
  • Chemoresistance in Brain Cancer and Different Chemosensitization Approaches (Amrita Devi Khwairakpam, Javadi Monisha, Kishore Banik, Harsha Choudhary, Anand Sharma, Devivasha Bordoloi and Ajaikumar B Kunnumakkara)
  • Phytochemicals as Chemosensitizers in Breast Cancer (Madhumita Roy, Ruma Sarkar, Apurba Mukherjee, Sutapa Mukherjee and Jaydip Biswas)
  • Potential of Different Chemosensitizers to Overcome Chemoresistance in Cervical Cancer (Kishore Banik, Bethsebie Lalduhsaki Sailo, Krishan Kumar Thakur, Aviral Jaiswal, Javadi Monisha, Devivasha Bordoloi and Ajaikumar B. Kunnumakkara)
  • Colon Cancer Chemoresistance and Chemosensitization (Muthu K Shanmugam, Arunasalam Dharmarajan, Frank Arfuso and Gautam Sethi)
  • Cancer Cell Chemoresistance and Chemosensitization in Endometrial Cancer (Anuj Kumar Singh, Javadi Monisha, Kishore Banik, Harsha Choudhary, Amrita Devi Khwairakpam, Devivasha Bordoloi and Ajaikumar B Kunnumakkara)
  • Different Approaches to Overcome Chemoresistance in Esophageal Cancer (Devivasha Bordoloi, Kishore Banik, Amrita Devi Khwairakpam, Anand Sharma, Javadi Monisha, Bethsebie Lalduhsaki Sailo and Ajaikumar B Kunnumakkara)
  • Different Chemosensitization Approaches in Gastric Cancer (Harsha Choudhary, Devivasha Bordoloi, Jai Prakash, Nafiseh Manteghi, Ganesan Padmavathi, Javadi Monisha and Ajaikumar B Kunnumakkara)
  • Chemoresistance and Chemosensitization in Hematological Malignancies (Ota Fuchs)
  • Different Methods to Inhibit Chemoresistance in Hepatocellular Carcinoma (Anuj Kumar Singh, Nand Kishor Roy, Anand Anip, Kishore Banik, Javadi Monisha, Devivasha Bordoloi and Ajaikumar B Kunnumakkara)
  • Different Chemosensitization Approaches for the Effective Management of HNSCC (Krishan K. Thakur, Devivasha Bordoloi, Jai Prakash, Javadi Monisha, Nand Kishor Roy and Ajaikumar B Kunnumakkara)
  • Lung Cancer Chemoresistance and Chemosensitization (Kenneth K W To and Christy Wing Sum Tong)
  • Chemoresistance and Chemosensitization in Melanoma (Javadi Monisha, Nand Kishor Roy, Anand Sharma, Kishore Banik, Ganesan Padmavathi, Devivasha Bordoloi and Ajaikumar B Kunnumakkara)
  • Strategies to Overcome Chemoresistance in Ovarian Cancer (Harsha Choudhary, Krishan Kumar Thakur, Anand Sharma, Nand Kishor Roy, Amrita Devi Khwairakpam, Devivasha Bordoloi and Ajaikumar B Kunnumakkara)
  • Molecular Alterations Involved in Pancreatic Cancer Chemoresistance and Chemosensitization Strategies (Bethsebie Lalduhsaki Sailo, Javadi Monisha, Aviral Jaiswal, Jai Prakash, Nand Kishor Roy, Krishan Kumar Thakur, Kishore Banik, Devivasha Bordoloi and Ajaikumar B Kunnumakkara)
  • Different Chemosensitization Approaches to Overcome Chemoresistance in Prostate Cancer (Ganesan Padmavathi, Javadi Monisha, Kishore Banik, Krishan Kumar Thakur, Harsha Choudhary, Devivasha Bordoloi and Ajaikumar B Kunnumakkara)
  • Therapeutic Strategies for Chemosensitization of Renal Cancer (Bethsebie Lalduhsaki Sailo, Devivasha Bordoloi, Kishore Banik, Amrita Devi Khwairakpam, Nand Kishor Roy, Jai Prakash and Ajaikumar B Kunnumakkara)

Readership: Scientists working in the field of cancer biology, cancer genomics and proteomics. Also specialists and researchers in diverse fields of disease pathogenesis as it provides collective information about fusion genes and cancer from the basics to the targeted therapies. Clinicians and scientists working in the field of oncology.
Keywords:Cancer;Chemoresistance;Chemosensitization;Combination;Multidrug Resistance;Natural Compounds;ChemotherapyReview:0


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